
Phentolamine mesilate
CAS No. 65-28-1
Phentolamine mesilate( Regitine | Vasomax )
Catalog No. M15480 CAS No. 65-28-1
Phentolamine Mesylate is a nonselective alpha-adrenergic antagonist.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
100MG | 46 | In Stock |
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200MG | 60 | In Stock |
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500MG | 138 | In Stock |
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Biological Information
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Product NamePhentolamine mesilate
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NoteResearch use only, not for human use.
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Brief DescriptionPhentolamine Mesylate is a nonselective alpha-adrenergic antagonist.
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DescriptionPhentolamine Mesylate is a nonselective alpha-adrenergic antagonist.(In Vitro):Phentolamine (0.1-1 μM) inhibits the response to Clonidine in rat ileum, with the pA2 and pKB of 7.92 and 8.07, respectively.Phentolamine (10-70 μg/mL; 48 h) inhibits proliferation of HDMECs and HBMECs in a dose-dependent manner, with IC50s of 50 μg/mL and 30 μg/mL without toxicity, respectively.Phentolamine (10-20 or 20-40 μg/mL; 12-48 h) signi?cantly delays scratch wound closure of HBMECs and HDMECs in a dose-dependent manner.Phentolamine (30 or 50 μg/mL; 4-12 h) inhibits tube formation of HBMECs and HDMECs.(In Vivo):Phentolamine (1 mg/kg; i.v.) produces hypotension and tachycardia in rats.
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In VitroPhentolamine (0.1-1 μM) inhibits the response to Clonidine in rat ileum, with the pA2 and pKB of 7.92 and 8.07, respectively.?Phentolamine (10-70 μg/mL; 48 h) inhibits proliferation of HDMECs and HBMECs in a dose-dependent manner, with IC50s of 50 μg/mL and 30 μg/mL without toxicity, respectively.Phentolamine (10-20 or 20-40 μg/mL; 12-48 h) signi?cantly delays scratch wound closure of HBMECs and HDMECs in a dose-dependent manner.Phentolamine (30 or 50 μg/mL; 4-12 h) inhibits tube formation of HBMECs and HDMECs.
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In VivoPhentolamine (1 mg/kg; i.v.) produces hypotension and tachycardia in rats.
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SynonymsRegitine | Vasomax
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PathwayEndocrinology/Hormones
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TargetAdrenergic Receptor
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Recptorα-adrenergic receptor
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number65-28-1
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Formula Weight377.46
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Molecular FormulaC17H19N3O·CH4O3S
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Purity>98% (HPLC)
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SolubilityEthanol: 76 mg/mL (201.34 mM); Water: 76 mg/mL (201.34 mM); DMSO: 76 mg/mL (201.34 mM)
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SMILESCS(O)(=O)=O.CC1=CC=C(C=C1)N(CC1=NCCN1)C1=CC(O)=CC=C1
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Chemical Name3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(p-tolyl)amino)phenol methanesulfonate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Giussani DA, et al. J Physiol. 1995 Jul 1;486 ( Pt 1):249-55.
molnova catalog



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